Explain realistic optimism11/11/2023 Among the possible explicative hypotheses, two seem to best describe results: optimism may have a direct effect on the neuroendocrine system and on immune responses, and it may have an indirect effect on health outcomes by promoting protective health behaviors, adaptive coping strategies and enhancing positive mood. Cancer, cardiovascular disease, respiratory failure, and aging with multimorbidity were considered. Only studies that explicitly included optimism and health outcomes, as measurable variables, and that reported a clear association between them have been reviewed. Optimists view desired goals as obtainable, so they often confront adversities in active manners resulting in perseverance and increased goal attainment. Dispositional optimism can be considered as facet of personality that is cognitive in nature which holds the global expectation that the future will be plenty of good events. The aim of this mini review is to explore the literature derived from clinical and experimental research assessing the associations between dispositional optimism and health status. To date lot is known for which diseases optimism is relevant, instead much less is known about how optimism interacts with other factors, both biological and psychological, in determining health status. The increasing interest about dispositional optimism’s role in health status and its positive modulating effect on health outcomes has led to a remarkable scientific production in the last decade. 2Allergy and Respiratory Diseases Clinic, Department of Internal Medicine, University of Genoa – IRCCS AOU San Martino-IST, Genova, Italy.1Psychology Unit, Scientific Institute of Montescano, Salvatore Maugeri Foundation, Istituto di Ricovero e Cura a Carattere Scientifico, Montescano, Italy.Giulia Avvenuti 1 Ilaria Baiardini 2 Anna Giardini 1*
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